In a recent paper from 1st December 2021, four endocrinologists lent their name to the recommendation that: “adolescents should not be given testosterone to treat gender incongruence under any circumstances because of these factors.”

http://gendersanity.org/

Note: These are links to articles, research papers and testimonials. Some resources are duplicated.

Addiction

Liver And Other Cancers

Heart Disease , Including Both Atherosclerosis And Heart Tissue Damage

Diabetes

Kidney Disease

High Blood Pressure

Joint/Bone Disease

Depression

Ovarian Cysts/PCOS

Fibroid Tumors

Painful Orgasm

Vaginal Atrophy (Burning, Itching, Painful Intercourse, Discharge)

Pelvic Pain Leading to Hysterectomy

Incontinence

Urinary Tract Infections

Painful Clitoromegaly

Babies Born With Birth Defects Including Blindness And Club Feet

Infertility And Miscarriage

Violent Mood Swings, From Euphoria To Rage

Worsening of Underlying Manic or Psychotic Conditions

Weight Gain

Persistent Hoarseness And Loss of Voice Projection

Acne

Baldness

Sleep Apnea

Increased Risk Of Dementia

Premature Death

Headaches and Visual Disturbances

Blood clots

This list of known side-effects of testosterone is not exhaustive. Furthermore, there are likely to be more sources of good evidence coming to light all the time. Please let us know if you find something of interest, and we shall update this reference.

Further reading:

The widespread use of testosterone to dope female athletes in East Germany in the 1980’s means that there is longitudinal evidence of the catastrophic harm done by giving large doses of male hormones to females:

https://www.zeit.de/sport/2018-03/doping-ddr-sport-dopingopfer-kinder-folgen-hilfe-english/komplettansicht

See also: Faust’s Gold: Inside the East German Doping Machine by Steven Ungerleider