This paper from Psychoneuroendocrinology (Volume 74, December 2016, Pages 371-379) reports on subcortical gray matter changes in transgender subjects after long-term cross-sex hormone administration.

Assessing the influence of high-dose cross-sex hormone administration on the brain.

Inclusion of transgender participants undergoing hormonal treatment.

Subcortical brain changes in areas related to cognition and emotion.

Changes in progesterone levels correlate with changes in gray matter structures.

https://doi.org/10.1016/j.psyneuen.2016.09.028

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